Our PAD Technology™ formulation and drug delivery system offer several unique advantages in the development of potent innovative new topical therapies for auto-immune and inflammatory conditions, including stability, tolerability, delivery to target tissue and convenience of use in daily routines.
PAD Technology™ characteristics
Traditionally, oil and water are combined with emulsifiers to bind them together. When high quantities of emulsifiers are used, it can cause a “wash out” of the skin’s own protective substances, such as the multilamellar lipids, when rinsed. Too much emulsifier can also cause stinging or burning in fissured or broken skin.
PAD™ formulations are special made oil-in-water dispersions in which the internal oil phase is stabilized by encapsulation in a multimolecular robust aqueous film of emulsifiers. Each PAD™ droplet maintains its own physical-chemical stability without the need of excessive presence of emulsifiers in the external phase and can be made with 10-15-fold less emulsifiers compared to conventional emulsions. This robustness of the oil-drops allows an expanded formulation space where we can use a greater variety of ingredients in higher concentrations thereby avoiding use of allergenic ingredients such as propylene glycol. This makes PAD™ formulations highly tolerable even on sensitive tissue.
The manufacturing of PAD™ formulations affords unsurpassed versatility in selection of pharmaceutical grade oils, solvents, surfactants, preservatives and other ingredients of choice. PAD™ vehicles can be made in a variety of dosage forms.
Our ambition was to address all four key areas:
- Chemical stability: Protects molecules from water
- Physical stability: Reduced risk of droplet collapse enables a broader formulation space for stability and solubility using non-allergenic ingredients
- Tolerability: Several fold less emulsifiers compared to conventional creams and lotions
- Delivery – efficacy: Fully solubilized active ingredients, optimal saturation, and optimal delivery of actives to target tissue
For more information, please visit www.padcream.com.